Hi There,
I ran a quick test here with a Win 7 client (192.168.181.139) running Autocad and the CadWorx overlay. The image below shows what network activity was associated with the client when Autocad and the CadWorx appplications were running.
From an application point of view (1) I did not see anything unusual. Some file share traffic as I saved the drawings out onto a Windows file share which you can see in (2). There is outbound connectivity with the Autocad website (3) and I assume this is to check for updates. If there was a slow down in my case I would be looking at connectivity to the file shares, as you can see below the AutoCad\CadWorx apps create tmp files so if access is slow the apps may suffer.
I did see reference in the CadWorx documentation that you can save data onto SQL databases so if you have this setup you may see activity on the default SQL port (TCP 1433)
Darragh